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当前位置: Science » 生物化学 » Science:科学家们可以“看穿”这些老鼠


摘要 : 拥有透视眼看穿物品听起来就像是漫画书里才会有的故事,但研究人员已经找到一种方法可以把整个动物变透明——从它们的大脑到其骨头。




Scientists can see through these rodents


Seeing through objects may seem like something straight out of a comic book, but researchers have found a way to make entire animals transparent—from their brains to their bones. The method lets fluorescent proteins visibly shine through bodies, lighting up entire vascular systems (above) and other structures. To produce such light shows, researchers treat euthanized rodents with several organic solvents to remove the water and lipids that made them opaque. The technique is dubbed uDISCO because it’s a variant of the original DISCO technique, which stands for 3D imaging of solvent-cleared organs. Although other methods like CLARITY or PARS can similarly create transparency in animal tissues, uDISCO does it for the whole body in just a few days as opposed to weeks or months. This technique allows the highest resolution images yet for a whole body, its creators report online today in Nature Methods. That should help scientists better see how a disease affects neurons throughout the body—like how a stroke can cause neuromuscular weakness—because it’s nearly impossible to reconnect the millions of neurons throughout a rodent body once dissected. uDISCO isn’t just limited to nervous system studies, either. Its applications are nearly endless, giving any scientist the seemingly superhuman ability to see through rodents.

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