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Science:白细胞在血管上钻洞并自动恢复

摘要 : 白细胞会一直在你的血管壁上撕开孔洞。但这些免疫系统卫士这么做是为了保护你:如果它们需要穿越血流到达感染组织(它们会在那里制作抗体并吞噬掉外来入侵者),它们首先需要到达血管内部的通道。

白细胞会一直在你的血管壁上撕开孔洞。但这些免疫系统卫士这么做是为了保护你:如果它们需要穿越血流到达感染组织(它们会在那里制作抗体并吞噬掉外来入侵者),它们首先需要到达血管内部的通道。

现在,科学家发现了它们如何在不对血管造成永久性损伤的情况下做到这一点,因为它们会每天钻进钻出血管壁达到10次以上。

首先,研究人员在其细胞核和血管壁结构纤维上加入荧光标记,血管壁可以阻挡外来颗粒并封住血液、血浆和免疫细胞。研究人员接来下用视频显微镜跟踪了这一过程。他们发现,血管细胞并非此前认为的切开小口的细胞。取而代之的是,免疫细胞会穿过血管壁。

通过软化其体积较大的细胞核并将其推动到细胞前缘,白细胞能够用探针分开血管壁中的过渡支架然后挤入其内部,研究人员在1月17日在线发表于《细胞报告》的论文中报告了这一成果。

这个过程会折断像纺线一样形成血管壁活动支架的更细小的纤维。随后作为常规细胞维持的一部分,这些细胞会轻而易举地修复那些裂痕。研究人员希望利用他们的发现更好地了解转移性癌细胞如何迁徙到血液内部并在整个机体中散播癌症。

原文链接:

How white blood cells rip holes in your blood vessels—and how your blood vessels recover

原文摘要:

White blood cells are constantly tearing holes in your blood vessel walls. But these guardians of the immune system are doing it to protect you: once they ride through the bloodstream to infected tissues—wher they make antibodies and eat foreign invaders—they need a way to get inside. Now, scientists have discovered just how they do it without permanently damaging blood vessels, which they slip into and out of up to 10 times each day. First, researchers added fluorescent tags to their nuclei and to the structural fibers of blood vessel walls, which keep out foreign particles and seal in blood, plasma, and immune cells. The researchers then tracked the process with video-microscopy. They found that blood vessel cells were not the ones making the openings, as previously thought. Instead, immune cells make their own way across. By softening their bulky nuclei and pushing them to the front edge of their cells, white blood cells probe apart scaffolding in the blood vessel walls and squeeze through, researchers report online today in Cell Reports. This process (seen above) snaps smaller, threadlike fibers that form the flexible scaffolding of blood vessel walls; the cells easily repair that breakage later as part of routine cellular maintenance. The researchers hope to use their discovery to better understand how metastatic cancer cells migrate into the bloodstream and spread cancer throughout the body.

来源: Science 浏览次数:0

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