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Science:聆听蛋白折叠的乐章

标签:蛋白质 折叠
摘要 : 蛋白质是组织和器官的基础构件单元,还能调节基因如何表达。因此,了解它们如何工作非常重要,科学家通常会利用视觉图像和图表了解它们如何工作。

 

蛋白质是组织和器官的基础构件单元,还能调节基因如何表达。因此,了解它们如何工作非常重要,科学家通常会利用视觉图像和图表了解它们如何工作。

现在,研究人员已经找到了一种分析蛋白质如何发挥作用的新方法:音乐。

受此前将信息与声音相结合研究的启发,比如发现引力波的著名的“唧唧声”,研究人员决定将音高和节奏与三种蛋白不同的特质相结合,包括它们的化学性质、亲水性以及结构。然后,他们利用生成旋律的软件,将不同的音符聚集在一起,形成可以在钢琴上弹奏的旋律。

为了展示这些听觉表现和视觉表现一样好用,研究人员接下来请一组参试者(大多数是研究音乐和蛋白质的学生)聆听这些旋律,并将其与图像相匹配。研究人员今年10月报告称,即便没有诸如卡拉OK歌词同步滚动条等视觉助手的辅助,他们至少在70%的情况下是正确的。

研究人员表示,这意味着这些纪录或可让研究人员利用他们的耳朵和眼睛,分辨诸如阿尔茨海默氏症等基因疾病的指示性蛋白模式。

原文链接:

Listen to the music of proteins folding

原文摘要:

Proteins, the building blocks of tissues and organs, also regulate how genes are expressed. So it’s important to determine how they work, something scientists typically do with visual images and graphs. Now, researchers have come up with a new way for analyzing how proteins function: music. Inspired by previous research mapping data to sound—like the famous "chirp" from the detection of gravitational waves—researchers decided to assign a musical pitch and rhythm to different qualities of three proteins, including their chemistry, affinity to water, and structure. Then, using melody generation software, they strung together the different notes to create melodies that could be played on a piano. (You can listen below.) To show that these auditory representations were as good as the visual ones, the researchers next asked a group of participants—mostly students who had studied both music and proteins—to listen to the melodies and match them to the images. They were right at least 70% of the time, even without the help of a visual aid, like the synchronized scroll bars often seen with karaoke lyrics, the scientists reported last month in Heliyon. This means, they say, that these recordings might allow researchers to use their ears, along with their eyes, to identify protein patterns indicative of genetic diseases like Alzheimer’s.

来源: Science 浏览次数:0

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